At least I don't have to be an asshole online to rational nice people just trying to prevent unnecessary suffering. It has been around since 2010 and has so far earned the reputation of delivering Adderall-like effects using earth-grown nutrients.. I recently tried Alpha GPC because I heard it can help with ADHD. On its own it can really improve my workouts and motivation outside the gym. I don't drink coffee, sugar drinks rarely, my drink of choice is black tea, and i only have it in the morning before work. After around 1 hour i felt a strange concentration feeling in my brain, the kind of feeling you have when you are hard at work on a paper for several hours and are completely submerged in the process. Alpha GPC (α-Glycerophosphocholine) is a popular nootropic supplement that can improve memory and learning, boost mood and energy, and prevent cognitive decline. sad, lethargic and I was acting like a whiner. The only bad thing i can note is that my strive to be more productive adds to my eye strain, in the long run since i work a lot with a computer, New comments cannot be posted and votes cannot be cast. New comments cannot be posted and votes cannot be cast. Best Forms of Choline Supplements Alpha GPC . I get the same depressive episodes from CDP or GPC. I was also quite foggy on it and the effect lasted for a good 12-16 hours every time I tried it. It's also used as a mild stimulant to boost energy and power output when exercising. L-Tyrosine. It enhances memory and gives your brain the raw materials to make plentiful acetylcholine, a valuable neurotransmitter. In addition to more restricted introduction to your system, learning more about the chemicals before taking them is a must. Please, that sort of personal attack is not at all helpful to the community here. L-Alpha Glycerylphosphorylcholine (Alpha GPC) The Alpha GPC form of choline is one of the most potent. No, depressive symptoms are actually very common with choline supplements. It is one of the most common side effects of stronger cholinergics, and one I warn people about all the time. I used to take it all the time, 300mg twice a day with some good results. This has happened to me twice before but to a lesser degree, and it only lasted 2 days. Second thing i noticed , i have become less lazy, even when i feel lazy my brain practically tries to push me to do things, i require less rest and my overall sleep quality has increased. From this increased acetylcholine synthesis, the benefits above are manifested. [2] Alpha GPC powder is usually the most expensive of the three forms shown. Alpha-GPC boosts physical performance. I'm taking all of these for depression and some anxiety (mostly social anxiety) and ADD/ADHD. Concerning the sex drive, well i can't really say for sure, could have been a placebo effect on this one ( i did read the case of the uncontrollable libido of that 79 year old man) (i'm happily married, i get enough sex every 1-3 days) It seemed like i had a bigger sex drive but nothing i could call abnormal. Discussion of nootropics and cognitive enhancers. Caffeine pills. Alpha GPC is a Nootropic Compound that is known to improve physical performance and boost brain function. Dosage. Our bodies seem to respond the same way to these two choline supplements as they do to dietary sources of choline. I dosed 300mg of the stuff and went into a 3-day long depressive-like episode where all the joy was sucked out of life. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. CDP-Choline is also a prodrug of uridine, and uridine can be good or bad depending on the person. I've never tried Alpha-GPC, but I can say that I've noticed positive effects from Choline. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587265/, https://www.reddit.com/r/Nootropics/comments/2bg0yy/be_careful_when_using_alpha_gpc/. You only get one brain! I took about 1200mg for the first week, then about 650mg every night. Alpha-GPC didn't make me alert so much as unable to fall asleep. [2] Alpha GPC is shown to also use DHA to help promote nerve growth. I took A-GPC every day for a week without any notable side effects. I get really sore and tired body load towards the end of the day after a combo of alpha-gpc and aniracetam. I just wanted to make a quick comment about the dangers of alpha gpc. 1. So here is my story, I've been reading a lot before considering to buy A-GPC, had my doubts at first and was eagerly awaiting my shipment to arrive. Particularly with higher doses, stronger supplements such as Alpha-GPC, or in people who are predisposed to depressive symptoms. I realized after 3 days that I took the choline and some piracetam brought me up pretty quickly. I just wanted to make a quick comment about the dangers of alpha gpc. Alpha gpc is underrated imo when ppl say its optional to dose it alongside racetams for headache prevention. I wasn't jittery nor did I have a headache that typically occurs with stimulants. So that's where the idea came from, i need a little bit of external help. I will try Alpha-GPC and note any differences. 5-HTP. This is yet another reason why more regimented testing is required when you try a new supplement. I am normally extremely careful, this was a lapse in judgement. I like Alpha-GPC way better than CDP Choline. It was absolutely horrible. Aniracetam. Was the depression angry and active or sad and lethargic? The depressive feelings come on quick, and take a couple days to dissipate. One of the best Adderall alternatives is known as alpha GPC (choline alfoscerate), a choline supplement. Also for the sake of experiment i have taken A-GPC before bed a few times, well, it's harder to fall asleep , the dreams are more vivid. This supplement is noted as a nootropic, a more natural alternative for reducing symptoms of ADD and ADHD. Therefore, it isn't at all surprising that choline supplementation would promote depressive experiences. Discussion of nootropics and cognitive enhancers. Happened 3 times already in the past and I have not gone back to test each one individually because the body load was horrendous and I need a day when i don't have any work or plans to reinvestigate if its individual or combo causing it. It increases physical strength and makes you produce more human … Anyone here get different results depending on the type of choline? It is not atypical by any sense of the word. I don't know what else to share so i'll continue to my experience. I currently work at a job that requires a lot of thinking, documents, technical things , cant really go much into detail, so each day i have to work with my brain a lot. Any choline makes me sad and depressed, except for eggs. Alpha-GPC is a nootropic. Ended up quitting it because the price was high compared to CDP choline and I couldn't tell the difference. Alpha GPC works fast and helps deliver choline to the brain and actually increases the production of acetylcholine along with cell membrane phospholipids. It could be worse :D I got super horny on A GPC :D Just can't use it because of this. About two weeks ago I started "realizing" how much more verbal I was when around people. Hippocampal cholinergic signaling is heavily implicated in depressive and stress-related disorders: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587265/ Note that increased ACh signaling to the hippocampus promotes depressive and anxiety-like behaviors, and Fluoxetine (Prozac) has been demonstrated to reduce cholinergic tone in the hippocampus. Piracetam … Your body and brain loves it when you use Alpha GPC. It was like a non-ideal Ritalin in that it kept me awake but didn't make me feel or think any better -- to the contrary. It is worth to mention that i have a strong analytical mind and strong cognitive abilities. What is Alpha GPC. One property most consumers are after is the increased production of the human growth hormone and help in muscle toning. It works on its own as a powerful memory booster. I had no bad side effects, my mood became better, i constantly feel this drive inside to become more productive. Like, CDP-choline, daily supplementation of Alpha GPC need not be high. Alpha Brain is a product of a supplement manufacturing company that goes by the name Onnit. Alpha-GPC has two distinct but very different effects. CDP puts me in a terrible mood. The latter makes me depressed more, while the former makes me feel more thoughtful and pensive. Alpha GPC is contained in many foods, such as oats, milk, cheese, yogurt, and eggs. This has happened to me twice before but to a lesser degree, and it only lasted 2 days. Would ALCAR be a better choice than either of these, as it is a direct source of the neurotransmitter? I wanted to alert people to the possibility that AGPC CAN cause these effects. Choline is one of the best brain boosters and a powerful precursor to the neurotransmitter Acetycholine. And afterwards tested A-GPC a week at work. Press question mark to learn the rest of the keyboard shortcuts. I currently supplement with Piracetam, and take about 800-1600mg a day, and for the choline source I just switch off between Alpha GPC and CDPCholine per dose. Also don’t forget the fish oil, and I personally think you would benefit from a bioavailabile Magnesium supp, perhaps Glycinate. No, you want to share a subjective experience that would be highly atypical of Alpha-GPC. Thankfully we know this because people like myself decide to despite to post about it: https://www.reddit.com/r/Nootropics/comments/2bg0yy/be_careful_when_using_alpha_gpc/, https://www.reddit.com/r/Nootropics/comments/352c0c/how_long_does_depression_from_alpha_gpc_last_is/, 3-day long depressive-like episode where all the joy was sucked out of life it was absolutely horrible panic attacks. Alpha-GPC didn't make me alert so much as unable to fall asleep. Because it doesn’t have to cannibalize its own cells to get more choline. St.jhon's Wort Ginseng Ashwagandha Ginkgo Biloba Mucuna Pruriens BACOPA monnieri Rhodiola Rosea. why the fuck would you keep taking it another 2 or 3 times? In other words, it makes your brain stronger. thought there was something really wrong with my brain. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic) refers to one of three glutamate receptors in your brain.. This effect is compounded by the nootropics community frequently insisting that negative experiences are somehow atypical or ascribing the depressive symptoms to operator error, which is not the case. For this reason, Alpha GPC would be a safe and effective natural Adderall substitute for improving focus and concentration in the user. Thus, alpha GPC is often used … Alpha GPC naturally occurs in your brain as a byproduct of phosphatidylcholine … So i have been noticing that after about 5 hours of work, my mind gets foggy, it's hard to concentrate (not eye strain, already won a war against that). To my surprise 30 minutes after taking it my mood lifts and I feel incredibly focused and motivated, I spent a few hours doing some math lessons online and loved it. Good advice though, thanks. Alpha GPC. It’s known as a Choline pro drug, meaning it increases the concentration of Choline in the brain. The first time I took Choline (by itself), I felt so clear-headed, but that effect has mitigated since. Piracetam. Piracetam isn’t so much a calming agent like the other nootropics on this list. Before experimenting i took a vacation to analyze myself in a stress free environment. It was better than Modafinil. It is commonly marketed in Europe under brand names like Delecit and Gliatalin, which are also labeled as “memory enhancers”. The alpha gpc is absolutely awesome. Depression is a sign of too much choline. Alpha GPC increases this chemical within the brain, thereby leading to enhanced memory and cognition. So I've read elsewhere that Alpha GPC causes depressive side effects. If anything that's a sign of a greater mental problem than making one poor supplement choice. Happened 3 times already in the past and I have not gone back to test each one individually because the body load was horrendous and I need a day when i don't have any work or plans to reinvestigate if its individual or combo causing it. You probably don't need more choline. Alpha GPC is a natural compound that can also work well with other nootropics. It is a fat-soluble ampakine nootropic. That only happened the third time I took it. The suggested dosage is 600 mg (about ¼ tsp) once or twice a day with water. It works so well that it’s prescribed throughout Europe for memory loss (it’s over-the-counter in the U.S.). Press J to jump to the feed. The racetam-class of nootropics have a pyrrolidone nucleus at their core. The first similarity between these two is that they are both nootropics. And turns it into Alpha GPC. That's interesting, does this mean that anticholinergics like Benadryl would be of use? When it comes to this stack I keep the same 750mg dose for Oxiracetam. Alpha GPC works by crossing the blood-brain barrier and promptly increasing levels of usable acetylcholine. Alpha gpc and uridine are my fav mood enhancers. Sometimes it gives fatigue/inflammation/depression. You can most certainly use other choline sources out there or just have a diet rich in choline but I personally like Alpha GPC the most. I am glad that you are well again but please be more careful. The first time nothing bad happened and the second time it was mild. My hunch is that phosphatidylcholine and lecithin are more mood friendly cholinergics but have slower uptake vs. CDP choline for example, which is why many overlook these as cholinergics for their stack. Pros Citicoline is the most bioavailable form of choline, but alpha GPC is also a good source. What i have felt over this week: my memory became stronger, remembering things i used to learn, hear, see became a lot easier and a lot faster, it wasn't a miracle but a really great boost. A-GPC all the way for me. Similarities Between The Two. Alpha GPC naturally occurs in your brain as a byproduct of phosphatidylcholine (PC). It was like a non-ideal Ritalin in that it kept me awake but didn't make me feel or think any better -- to the contrary. Alpha GPC Benefits Alpha gpc nootropic happens to be one of the most effective sources of choline; which is useful in our bodies, as it is used to make a neurotransmitter that aids in memory and contraction of muscles. Then I add 1 or 2 capsules of Alpha-GPC which usually adds to be 150-300mg’s. Alpha GPC: Alpha GPC is another choline source with its own nootropic effects with or without a racetam through its ability to improve memory, focus, and concentration. The alpha GPC supplement enhances cognitive function in healthy adults by converting phosphorylcholine and ultimately into choline and acetylcholine. By weight, alpha GPC is considered the best acetylcholine precursor and can help mitigate age related degenerative diseases similar to citicoline. Those two are not mutually exclusive. Looks like you're using new Reddit on an old browser. It is the best choline source because of its complete bioavailability and can help to stabilize acetylcholine levels that may be temporarily depleted from the use of nootropics from the racetam class. This highly bioavailable form of choline quickly enters your brain.. As a nootropic supplement, Alpha GPC is about 40% choline by weight. Acetylcholine is an organic chemical that works as a neurotransmitter and is crucial for memory and learning functions. By using our Services or clicking I agree, you agree to our use of cookies. My work requires a lot of that. It can be found in the brain and in dairy products, but is typically produced synthetically by purifying soy lecithin. Citicoline vs Alpha GPC. Alpha GPC (choline) is a miracle for my ADHD and mood. After another hour, the feeling slightly diminished, and left me with a lighter but strong feeling of concentration. Choline is an essential nutrient that can also be found in food, particularly eggs. Gradually increase your dosage until you feel something, don't just take a dosage because that's what other people take. And Aniracetam is a Cholinergic compound, meaning it affects acetylcholine levels in the brain. Here is a short description of me so you can compare . Page 1 of 2 - Alpha GPC experience - posted in Brain Health: I have been taking Alpha GPC for a little over a month now. I wonder why that is. Alpha-GPC is a compound used for increasing cognition in the brain. Took my first scoop around midday and waited. Omega-3 fish oil Multivitamin Whey protein Creatine I get really sore and tired body load towards the end of the day after a combo of alpha-gpc and aniracetam. GABA. I must have been deprived of choline because before I was groggy all day and had some low level of brain fog. I ask this because I used CDP Choline for 3 days and ended with a bad depression that lasted for 1 week. Dont even need tianeptine wheb i consistently take the mrhappy stack This neurotransmitter is essential for attention and learning. In combination with other nootropics, it works as a potentiator boosting cognitive capabilities. I didn't know what was wrong, and I was dealing with panic attacks at the same time and I thought there was something really wrong with my brain. Cookies help us deliver our Services. I never noticed anything when I started, but I thought it would be a good idea to keep taking it. Alpha GPC is known for enhancing memory, focus, energy level and more. i bought A-GPC 50% and take a 500mg scoop every morning with my breakfast, could be a little bit more since i can't really tell by the scoop what is the perfect 500mg amount. Aniracetam is in the racetam-family of nootropic compounds. I didn't realize it was a known side effect. When your brain needs more choline, and the choline floating around in your brain is running low, it breaks down PC from cell membranes. I was also quite foggy on it and the effect lasted for a good 12-16 hours every time I tried it. It's fairly common for first-time users to not associate the depressive symptoms with the choline supplementation because they're expecting nootropic effects, not a depressed mood. I was not expecting a mega effect, a sudden "limitless" effect. There were so many intrusive thoughts - it felt like the only working parts of my brain were the amygdala and the prefrontal cortex. Choline chloride, Alpha-GPC, betaine, and CDP-choline (citicoline) are the common supplemental forms of choline. Alpha GPC is a choline source synthesized from sunflower or soy. Alpha GPC is no different. Well, maybe that explains why you kept taking it. Alpha GPC acts on the brain by increasing levels of available acetylcholine. Alpha GPC is an astounding nootropic that just like Uridine Monophosphate, provides an extensive variety of cognitive benefits to support overall brain health in the short-term and the long-term. On a side note, Alpha Brain (by Onnit) happens to have both huperzine serrata & Alpha GPC, though at a much lower dosage; 100mg and 40mg, respectively. Maybe I'm misjudging your post, but I don't think this type of hostility is necessary or appropriate for this subreddit. It's just me too but I've noticed it with CDP choline on its own. Sorry to hear about the ordeal, that sounds god-damned awful. The stack of Uridine and Alpha GPC on their own might cause mild potentiation of Ritalins effects, so that would be one thing to watch out for. Then why the fuck would you keep taking it another 2 or 3 times? I want to try Alpha GPC but I don't know if I'd get different results. There is a lot of research (for example, this 1996 study and this 2003 study) that points to a positive reaction with Choline and people with Bipolar disorder, so perhaps people without the disorder do not have the same, potentially positive experience with Choline. I am a white male 26 years old, around 135kg weight ( well built, sufficient muscle mass ( mostly from lots of manual labor) but accumulated some extra layers over the years). A big list of neurofeedback studies (adhd, depression, performance enhancement) | Looking for neurofeedback reports I wanted to investigate whether a local health clinic offering neurofeedback with neuroptimal device was legit and whether this neuroptimal device is capable of doing serious neurofeedback or if it's watered down bs, so I went to see what kind of studies were there. The suggested dosage is 600 mg (about ¼ tsp) once or twice a day with water. Recently i did a lot of different blood tests, which show no abnormalities, vitamins, minerals and everything possible is on the level. It pairs well with my Lamotrigine (for Bipolar II disorder) and also had a positive effect on a clinically depressed person I know that is taking medication. Low level of brain fog calming agent like the only working parts of my brain what was on... 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